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VYVANSE (lisdexamfetamine dimesylate), a CNS stimulant, is for once-a-day oral administration. The chemical designation for lisdexamfetamine dimesylate is (2S)-2,6-diaminoN-[(1S)-1-methyl-2-phenylethyl] hexanamide dimethanesulfonate. The molecular formula is C₁₅H₂₅N₃O•(CH₄O₃S)₂, which corresponds to a molecular weight of 455.60.

 

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Vyvanse is available as a fast-acting or slow-release tablet or chewable. The drug takes effect within about 2 hours of use and typically lasts 10-12 hours following the dose. It’s also normally prescribed in 10, 20, or 30mg pills or chewable tablets. This avoids many of the issues with Adderall, where users who can’t take pills are told to break the capsules open.  

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More than 10 million Americans are prescribed Vyvanse or its equivalents. Prescriptions are offered for ADHD, in combination with antidepressants, and for binge eating disorder. Here, Vyvanse is shown to be highly effective at helping individuals with ADHD. ADHD patients who take the grade show marked grade performance, work performance, self-esteem improvements, and reduction in self-harm and suicide attempts. While Vyvanse performs similarly to Adderall, it’s more and more preferred in medical settings because of duration of action. Vyvanse typically lasts 12 hours, or more than enough time for the average school or workday. Adderall typically lasts 6 and must be taken twice throughout the day.  

All amphetamines can be used as a physical and mental performance enhancer. Vyvanse is rarely used for performance enhancement (although it does happen). Instead, the drug is favored as a “study” drug. Here, students in high school and college use Vyvanse to increase focus, memory, working memory, and inhibition control. This makes it easier for students to study, to stay awake and alert for tests. Some studies suggest that as many as 35% of college students use amphetamine derivatives like Vyvanse for this purpose. At the same time, taking larger doses can result in cognitive deterioration rather than modest improvement. Here, users take anywhere from 20 to 50 mg of Vyvanse, usually spread out over the duration of their study.  

 

Lisdexamfetamine dimesylate is a white to off-white powder that is soluble in water (792 mg/mL).

Information for VYVANSE Capsules

VYVANSE capsules contain 10 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg, and 70 mg of lisdexamfetamine dimesylate (equivalent to 5.8 mg, 11.6 mg, 17.3 mg, 23.1 mg, 28.9 mg, 34.7 mg, and 40.5 mg of lisdexamfetamine).

Inactive ingredients: microcrystalline cellulose, croscarmellose sodium, and magnesium stearate. The capsule shells contain gelatin, titanium dioxide, and one or more of the following: FD&C Red #3, FD&C Yellow #6, FD&C Blue #1, Black Iron Oxide, and Yellow Iron Oxide.

Information for VYVANSE Chewable Tablets

VYVANSE chewable tablets contain 10 mg, 20 mg, 30 mg, 40 mg, 50 mg, and 60 mg of lisdexamfetamine dimesylate (equivalent to 5.8 mg, 11.6 mg, 17.3 mg, 23.1 mg, 28.9 mg, and 34.7 mg of lisdexamfetamine).

Inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, guar gum, magnesium stearate, mannitol, microcrystalline cellulose, sucralose, artificial strawberry flavor.

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